AB1533 DIAGNOSTIC VALUE AND BENEFITS OF PERFORMING A MINIMALLY INVASIVE TECHNIQUE FOR MINOR SALIVARY GLAND BIOPSY, A CASE SERIES

Background Salivary gland biopsy plays an important role in the diagnosis of systemic diseases, especially Sjögren’s Syndrome. Minimally invasive has a low risk complications with respect to classical technique, without losing its diagnostic capacity. Objectives To assess utility and safety minimally technique patients suspected disease salivary involvement. Methods Retrospective analysis 31 minor biopsies performed by our Systemic Autoimmunity Disease Unit from November 1th 2020 2022, using technique. Antibody profile histopathological changes observed were recorded. Adverse events registered immediately after procedure at next medical visit. Results A total reviewed. Mean age was 60 years, most women (n=27, 87%). The success rate obtaining glandular tissue 94% (29/31). With immunological data, 24 had positive ANAs (77,4%), negative ENAs (77.4%) 21 Rheumatoid Factor (67.7%). In evaluation 52% normal (n=16), 23% focal lymphocytic sialadenitis (n=7), 16% nonspecific chronic (n=5), 6% (n=2) non-existent or insufficient sample 3% fatty infiltration (n=1). only complication transient superficial lip ecchymosis one patient (3,2%). Conclusion immunonegative sicca syndrome are diagnosed Sjögren´s Syndrome due This is simple tool which saves time until complications. References [1]Colella G, Cannavale R, Vicidomini A, Itro A. biopsy: comprehensive review techniques related Rheumatology (Oxford). 2010 Nov;49(11):2117-21. doi: 10.1093/rheumatology/keq225. Epub Jul 25. PMID: 20660500. [2]Teppo H, Revonta M. follow-up study syndrome. Clin Rheumatol. 2007 Jul;26(7):1099-103. 10.1007/s10067-006-0457-1. 2006 Nov 17522950. Figure 1. Acknowledgements: NIL. Disclosure Interests None Declared.